Several others were also left injured in the early morning attack.
The deceased were seasoned politicians in their native county in Kenya.
The septic tank is said to have caved in on Saturday evening.
Naomi Wangare was strangled to death after being lured out of her house via a phone call.
The snarl-up has led to several motorists spending the night in their cars.
The embattled CS has been antagonising the government since a tell-all briefing on January 12.
The crackdown took place in some high-end neighbourhoods including Lavington.
This followed a viral exposé by a popular social media blogger touching on sexual mistreatment and forced SACCO deductions.
The residents have been forced to shut down businesses and are calling for the government to intervene.
Mt Kenya is one of the few places with snow in Africa.